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Immunotherapy

Involuted TLS as a harbinger of HCC regression

Nature Immunology volume 25, pages 1986–1987 (2024)Cite this article

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Tertiary lymphoid structures (TLS) have different stages and cellular compositions in human tumors. New data are showing the effect of neoadjuvant immunotherapy on the fate of TLS in treatment-responsive versus treatment-resistant liver cancers.

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Fig. 1: Involuted TLS develop in regressed tumor beds after effective immunotherapy.

References

  1. Teillaud, J. L., Houel, A., Panouillot, M., Riffard, C. & Dieu-Nosjean, M. C. Nat. Rev. Cancer. 24, 629–646 (2024).

    Article  CAS  PubMed  Google Scholar 

  2. Schumacher, T. N. & Thommen, D. S. Science 375, eabf9419 (2022).

    Article  CAS  PubMed  Google Scholar 

  3. Shu, D. H. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01992-w (2024).

    Article  PubMed  Google Scholar 

  4. Calderaro, J. et al. J. Hepatol. 70, 58–65 (2019).

    Article  PubMed  Google Scholar 

  5. Sautès-Fridman, C., Petitprez, F., Calderaro, J. & Fridman, W. H. Nat. Rev. Cancer. 19, 307–325 (2019).

    Article  PubMed  Google Scholar 

  6. Ishigami, E. et al. Breast Cancer 26, 180–189 (2019).

    Article  PubMed  Google Scholar 

  7. Chelvanambi, M., Fecek, R. J., Taylor, J. L. & Storkus, W. J. J. Immunother. Cancer 9, e001906 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. van Hooren, L. et al. Nat. Commun. 12, 4127 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bod, L. et al. Nature 619, 348–356 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Finkin, S. et al. Nat. Immunol. 16, 1235–1244 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Yang, Y. et al. Cell 187, 4790–4811 (2024).

    Article  CAS  PubMed  Google Scholar 

  12. Zhang, Y. et al. Cancer Cell 42, 1370–1385 (2024).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Xin Liu & Dan G. Duda

  2. Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Xin Liu

Authors
  1. Xin Liu
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  2. Dan G. Duda
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Corresponding author

Correspondence to Dan G. Duda.

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Competing interests

D.G.D. declares research grants from Bayer, Exelixis, Surface Oncology, and Bristol Myers Squibb. X.L. declares no competing interests.

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Liu, X., Duda, D.G. Involuted TLS as a harbinger of HCC regression. Nat Immunol 25, 1986–1987 (2024). https://doi.org/10.1038/s41590-024-01990-y

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