Extended Data Fig. 3: β-glucan treatment does not induce the expansion of other immune cells following IAV infection.
From: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
(a) Mice were infected with IAV at day7 post β-glucan treatment. Frequency and total cell number in the lung parenchyma of neutrophils (b, c), monocytes (d), macrophages (e), T cells (f) and B cells (g) (n = 5). (h) Il10GFP reporter mice were infected with IAV at day7 post β-glucan treatment. Lungs were collected 6 days post IAV-infection. Frequency and total cell number of Il10-expressing cells (i), macrophages (j), monocytes (k), T cells (l) and B cells (m) in the lungs (n = 9). Data represented as mean ± SEM. Data were analyzed using two-tailed unpaired t-test (i-m) or two-way ANOVA followed by Sidak’s multiple comparisons tests(b-g). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Illustrations in a and h created using BioRender.com.
