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COVID-19

Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa

Cell-type-specific SARS-CoV-2-induced responses in nasal mucosa differ largely between ancestral, Delta and Omicron cases, including the association with severe disease and the cellular and immunological effects of prior vaccination.

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Fig. 1: SARS-CoV-2 variants induce specific responses in the nasal mucosa.

References

  1. Walsh, J. M. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-02052-z (2025).

    Article  PubMed  Google Scholar 

  2. Sungnak, W. et al. Nat. Med. 26, 681–687 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ziegler, C. G. K. et al. Cell 181, 1016–1035.e19 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Ziegler, C. G. K. et al. Cell 184, 4713–4733.e22 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Yoshida, M. et al. Nature 602, 321–327 (2022).

    Article  CAS  PubMed  Google Scholar 

  6. Puhach, O. et al. Nat. Med. 28, 1491–1500 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Carabelli, A. M. et al. Nat. Rev. Microbiol. 21, 162–177 (2023).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Lindeboom, R. G. H. et al. Nature 631, 189–198 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Montoro, D. T. et al. Nature 560, 319–324 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Lin, B. et al. Nature 629, 869–877 (2024).

    Article  CAS  PubMed  Google Scholar 

  11. He, X. et al. Front. Immunol. 14, 1181121 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Painter, M. M. et al. Nat. Immunol. 24, 1711–1724 (2023).

    Article  CAS  PubMed  Google Scholar 

  13. Lapuente, D. et al. Nat. Commun. 12, 6871 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Martijn C. Nawijn.

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van Baarle, D., Nawijn, M.C. Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa. Nat Immunol 26, 152–154 (2025). https://doi.org/10.1038/s41590-024-02067-6

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