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Insights into autoimmunity and cancer

Nature Immunology volume 26, pages 342–344 (2025)Cite this article

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In December 2024, the NIH Office of Autoimmune Disease Research in the Office of Research on Women’s Health (OADR-ORWH) hosted a virtual meeting in the ScienceTALKS series entitled ‘The Cancer Autoimmune Connection: Decoding the Paradox’.

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Fig. 1: Bidirectional interplay of the immune system in malignancy and autoimmunity.

References

  1. Franks, A. L. & Slansky, J. E. Anticancer Res. 32, 1119–1136 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Egiziano, G., Bernatsky, S. & Shah, A. A. Best Pract. Res. Clin. Rheumatol. 30, 53–62 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Steen, V. D. Rheum. Dis. Clin. North Am. 34, 1–15 (2008).

    Article  PubMed  Google Scholar 

  4. Joseph, C. G. et al. Science 343, 152–157 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Igusa, T. et al. Ann. Rheum. Dis. 77, 1179–1186 (2018).

    Article  PubMed  Google Scholar 

  6. Schreiber, R. D., Old, L. J. & Smyth, M. J. Science 331, 1565–1570 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Shah, A. A., Laiho, M., Rosen, A. & Casciola-Rosen, L. Arthritis Rheumatol. 71, 1571–1579 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Siddiqui, I. et al. Immunity 50, 195–211.e110 (2019).

    Article  CAS  PubMed  Google Scholar 

  9. Gearty, S. V. et al. Nature 602, 156–161 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. Lechner, M. G. et al. Sci. Transl. Med. 15, eadg0675 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chen, H.-C. et al. Preprint at bioRxiv https://doi.org/10.1101/2024.12.12.628206 (2024).

  12. Escobar, G., Mangani, D. & Anderson, A. C. Sci. Immunol. 5, eabb9726 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. International Multiple Sclerosis Genetics Consortium. Science 365, eaav7188 (2019).

    Article  PubMed Central  Google Scholar 

  14. Mangani, D. et al. Immunity 57, 2565–2582.e2566 (2024).

    Article  CAS  PubMed  Google Scholar 

  15. Cappelli, L. C. & Shah, A. A. Best Pract. Res. Clin. Rheumatol. 34, 101472 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The Office of Autoimmune Disease Research thanks the invited speakers and moderators for sharing their valuable expertise and perspectives on the intersection of autoimmunity and cancer immunology. We thank all the scientists who laid the groundwork for this discussion.

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Authors and Affiliations

  1. Office of Autoimmune Disease Research, Office of Research on Women’s Health, Office of the Director, National Institutes of Health, Bethesda, MD, USA

    Xinrui Li, Carmen Ufret-Vincenty, Jacqueline Robinson-Hamm & Victoria K. Shanmugam

  2. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Lillian Kuo

  3. National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA

    Heiyoung Park

Authors
  1. Xinrui Li
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  2. Carmen Ufret-Vincenty
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  3. Jacqueline Robinson-Hamm
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  6. Victoria K. Shanmugam
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Corresponding author

Correspondence to Victoria K. Shanmugam.

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Competing interests

This symposium was supported by the Office of Autoimmune Disease Research in the Office of Research of Women’s Health in the Office of the Director of the National Institutes of Health (NIH). All authors of this manuscript are employees of the NIH and have no competing interests.

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Li, X., Ufret-Vincenty, C., Robinson-Hamm, J. et al. Insights into autoimmunity and cancer. Nat Immunol 26, 342–344 (2025). https://doi.org/10.1038/s41590-025-02078-x

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