Once seen as a passive barrier, the dura mater is now recognized as an active immune site. A study now suggests that regulatory T cells within the dura mater modulate immune responses by restricting the production of IFNγ and controlling immune cell infiltration in the central nervous system (CNS) parenchyma.
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Acknowledgements
This work was partly funded by NMSS grant FG-2307-42179 awarded to G.G.D. and by a grant from NIH/NIA (AG034113) awarded to J.K.
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Davanzo, G.G., Kipnis, J. The brain’s regulators. Nat Immunol 26, 534–535 (2025). https://doi.org/10.1038/s41590-025-02116-8
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DOI: https://doi.org/10.1038/s41590-025-02116-8
