The US National Institute of Allergy and Infectious Diseases (NIAID) and the Foundation for the National Institutes of Health (FNIH) held a three-day workshop to assess the landscape of long COVID clinical studies and develop plans for the RECOVER-TLC clinical trials program.
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References
Al-Aly, Z. et al. Nat. Med. 30, 2148–2164 (2024).
Fang, Z., Ahrnsbrak, R. & Rekito, A. JAMA 332, 5–6 (2024).
Goldowitz, I., Worku, T., Brown, L. & Fineberg, H. V. (eds). A Long COVID Definition: A Chronic, Systemic Disease State with Profound Consequences page 3 (National Academies Press, 2024).
Montealegre Sanchez, G. A. et al. Pediatr. Res. https://doi.org/10.1038/s41390-024-03777-1 (2024).
Gross, R. S. et al. JAMA 332, 1174–1188 (2024).
Richard, S. A. et al. JAMA Netw. Open 6, e2251360 (2023).
Riley, S. et al. Wellcome Open Res 5, 200 (2020).
Al-Aly, Z., Xie, Y. & Bowe, B. Nature 594, 259–264 (2021).
VanElzakker, M. B. et al. Brain Behav. Immunity 119, 713–723 (2024).
Walitt, B. et al. Nat. Commun. 15, 907 (2024).
Feldstein, L. R. et al. N. Engl. J. Med. 383, 334–346 (2020).
Geng, L. N. et al. JAMA Intern. Med. 184, 1024–1034 (2024).
Kalil, A. C., Huttner, A. & Gomez, C. A. JAMA 330, 321–322 (2023).
Hurst, H. & Bolton, J. J. Manipulative Physiol. Ther. 27, 26–35 (2004).
Collins, F. et al. Science 379, 441–444 (2023).
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The authors acknowledge Rose Li and Associates, Inc. for the workshop transcript.
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Breen, J.J., Eisinger, R.W., Read, S.W. et al. Navigating the path forward for evidence-based management of long COVID. Nat Immunol 26, 536–539 (2025). https://doi.org/10.1038/s41590-025-02118-6
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DOI: https://doi.org/10.1038/s41590-025-02118-6