Extended Data Fig. 7: Dysregulation of the plasma proteome associated with perceived exertion in patients with long COVID recruited from Sweden.
From: Identification of soluble biomarkers that associate with distinct manifestations of long COVID
(a) Stacked histogram showing the distribution of correlation coefficients from pairwise comparisons of plasma protein concentrations versus Borg CR10 score for patients with long COVID (n = 95). Significance was evaluated using the two-tailed Pearson coefficient. (b) Gene set enrichment analysis (GSEA) showing plasma protein concentrations ranked by correlation with Borg CR10 scores for patients with long COVID (n = 95). Significance was evaluated using the GSEA method without correction. NES, normalized enrichment score. (c) Network analysis showing the corresponding differentially expressed plasma proteins from the inflammation panel depicted using Cytoscape. Each node represents a protein. Node color indicates protein concentration, and node size indicates significance. Red denotes overexpression in patients with a moderate Borg CR10 score, and blue denotes underexpression in patients with a moderate Borg CR10 score. Each edge represents the functional relevance between a pair of proteins, and line thickness represents the level of confidence.
