Fig. 3: LPS-induced gene programs in sepsis and COVID-19.
From: Systemic inflammation impairs myelopoiesis and interferon type I responses in humans
a, UMAP representation of LYZ+ blood monocytes from patients with early sepsis (n = 29) and early nonseptic infection (n = 17) and healthy controls (n = 19). b, UMAP representation of LYZ+ blood monocytes from patients with early stage mild (n = 11) and severe (n = 12) COVID-19 and sepsis (n = 13) and healthy controls (n = 10). c, Enrichment of NMF-inferred infMono gene program in LYZ+ blood monocytes from patients with early sepsis and nonseptic infection and healthy controls as in a. d, Enrichment of the NMF-inferred infMono gene program in LYZ+ blood monocytes from patients with early stage mild and severe COVID-19 and sepsis and healthy controls as in b. e, Box plots of infMono gene program enrichment in LYZ+ blood monocytes from patients with early sepsis and nonseptic infection and healthy controls as in a. f, Box plots of infMono gene program enrichment in LYZ+ blood monocytes from patients with early stage mild and severe COVID-19 and sepsis and healthy controls as in b. g, UMAP representation of CD3+ blood T cells from patients with early sepsis and early nonseptic infection and healthy controls as in a. h, UMAP representation of CD3+ blood T cells from patients with early stage mild and severe COVID-19 and sepsis and healthy controls as in b. i, Enrichment of NMF-inferred Tinf cell gene program in CD3+ blood T cells from patients with early sepsis and early nonseptic infection and healthy controls as in g. j, Enrichment of NMF-inferred Tinf cell gene program in CD3+ blood T cells from patients with early stage mild and severe COVID-19 and sepsis and healthy controls as in h. k, Box plots of the Tinf cell gene program enrichment in CD3+ blood T cells from patients with early sepsis and nonseptic infection and healthy controls as in g. l, Box plots of Tinf cell gene program enrichment in in CD3+ blood T cells from patients with early stage mild and severe COVID-19 and sepsis and healthy controls as in h. The box plots in e, f, k and l show the median, first and third quartiles and the whiskers 1.5× the IQR. The P values were calculated using two-sided, unpaired Wilcoxon’s signed-rank tests.
