Extended Data Fig. 2: IL-10 suppresses H3K27ac at genomic regions enriched in IRF1 binding motifs.
a–e, Additional analysis of H3K27ac CUT&RUN data shown in Fig. 2 obtained using monocytes from 2 independent donors and treated as depicted in Extended Data Fig. 1a. a, PCA plot of H3K27ac data for Resting, IL-10, LPS and IL-10 + LPS treatments of primary human monocytes. b, Bar plot depicting total number and the direction of regulation of the differentially regulated H3K27ac peaks relative to resting control. c, Hallmark pathway enrichment analyses of the genes associated with peaks in groups identified in Fig. 2a. d, UpSet plot showing interaction between suppressed genes identified in Extended Data Fig. 1e and individual groups of H3K27ac peaks from Fig. 2a. e, De novo motif analysis results using HOMER on Group 3 H3K27ac peaks. Created in https://BioRender.com.
