Extended Data Fig. 8: EOS301984 rescued cytokine production by isolated ‘exhausted’ CD8+ TILs in high adenosine concentrations.
From: Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
FACS analysis of cytokine production by TIM-3+ CD39+ CD8+ TILs isolated from a NSCLC sample (n = 1) and T cells from peripheral blood of healthy volunteers (n = 2), as indicated, stimulated with anti-CD3/CD28 microbeads for 72 or 48 h, respectively, in the presence of adenosine (100 µM) and/or EOS301984 (300 nM). Symbols in lower panel represent each donor (biological replicates), bars are mean value.
