Extended Data Fig. 9: EOS301984 overcomes the suppressive intracellular effects of adenosine on TIL functional expansion within the TME to enhance the anti-cancer immune response.
From: Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
The T cell boosting effect of ICB such as anti-PD-(L)1 agents may be limited by the presence of highly elevated concentrations of adenosine in certain TMEs. EOS301984 can act with A2AR antagonists to prevent suppressive effects of both intra- and extracellular adenosine, respectively, to enhance TIL expansion and function in such sites and may promote more effective overall immune responses during cancer immunotherapy. This schema was created in BioRender.
