Extended Data Fig. 4: Cross-reactive and BA.1-specific BMEM do not consistently increase over time post-infection.
From: Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections
a. Flow cytometry plot showing gating strategy for BMEM from a post-vaccination BA.1 infection. b. Plot showing quantification of WuHu1 and BA.1 RBD-specific CD19+IgD-IgM-CD27 + CD38- BMEM in primary BA.1 infection (n = 4) and post-vaccination BA.1 infection (n = 15) cohorts over time. Cells that bind both WuHu1 Spike and BA.1 RBD are quantified as cross-reactive Spike + , whereas cells that bind only BA.1 RBD are quantified as BA.1 RBD + . BMEM are quantified as a percentage of total PBMCs. Each symbol represents an individual. Lines connect timepoints from the same individual.
