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Towards evidence-based immunology

Nature Immunology volume 26, pages 980–982 (2025)Cite this article

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Immunology is in an unprecedented era of exciting exploration, made possible by powerful new tools and technologies. To capitalize on this progress and translate discovery to meaningful impact, a parallel culture of ‘evidence-based immunology’ must be developed.

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Fig. 1: The spectrum of research development in immunology, from exploration to actionable evidence.

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Acknowledgements

The authors wish to thank R. Thiebaut and F. Luciani for helpful comments on the manuscript.

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Authors and Affiliations

  1. Infection Analytics Program, Kirby Institute, UNSW Sydney, Kensington, New South Wales, Australia

    David S. Khoury, Deborah Cromer, Bronwyn Bailey, Shanchita R. Khan & Miles P. Davenport

  2. School of Biomedical Sciences, UNSW Sydney, Kensington, New South Wales, Australia

    Deborah L. Burnett

  3. Cellular Genomics Institute, UNSW Sydney, Kensington, New South Wales, Australia

    Deborah L. Burnett

  4. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

    Stephen J. Kent

  5. Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia

    Stephen J. Kent

  6. Department of Microbiology and Immunology, Cornell University, Ithaca, NY, USA

    Brian D. Rudd

  7. European Plotkin Institute for Vaccinology, Université libre de Bruxelles, Brussels, Belgium

    Arnaud Marchant

  8. School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia

    Tari Turner

Authors
  1. David S. Khoury
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  2. Deborah Cromer
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  3. Bronwyn Bailey
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  4. Shanchita R. Khan
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  5. Deborah L. Burnett
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  6. Stephen J. Kent
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  8. Arnaud Marchant
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  9. Tari Turner
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  10. Miles P. Davenport
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Corresponding author

Correspondence to Miles P. Davenport.

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Competing interests

M.P.D. and T.T. are co-leads of the Framework for Evidence Evaluation in Vaccine Assessment (FEEVA) initiative. The other authors have no conflicts of interest to declare.

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Khoury, D.S., Cromer, D., Bailey, B. et al. Towards evidence-based immunology. Nat Immunol 26, 980–982 (2025). https://doi.org/10.1038/s41590-025-02180-0

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