Extended Data Fig. 10: Model showing the role of MKRN2 in the regulation of IL-6 translation in homeostasis and inflammation resolution. | Nature Immunology

Extended Data Fig. 10: Model showing the role of MKRN2 in the regulation of IL-6 translation in homeostasis and inflammation resolution.

From: The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation

Extended Data Fig. 10

MKRN2 binds to the 3’ UTR of Il6 transcript and links the K29 poly-ubiquitin chain onto PAIP1 which disrupt the interaction between PAIP and eIF4A thus inhibit the closed-loop formation and subsequent translational initiation and maintenance of Il6 mRNA. Mkrn2 deficiency will increase the translational efficiency of IL-6 and lead to inflammation.

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