Extended Data Fig. 1: Analysis of the tumor immune infiltrate in transgenic Ptenpc-/-; Trp53pc-/- model.
From: Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
a-b) Gating strategy used to define the myeloid and lymphoid sub-populations. Representative FACS plot from the Ptenpc-/-; Trp53pc-/- model. c) Events are gated on CD45+ cells. d-e)% of naive, central memory, effector, effector memory and Treg cells gated on the (d) CD4+ subset and the (e) CD8+ subset. f-g) % of cells expressing functional markers gated on CD4+ and CD8+ cells. g) % of CD39+ cells gated on CD8+ cells. h) Cell Typist classification: each cluster is annotated with its predicted cell type. i) UCell score distribution in UMAP space for seven gene signatures. Statistical analyses were performed using two-tailed unpaired Student’s t test. Values are presented as mean ± SEM.
