Extended Data Fig. 4: Details for transcription factor results with respect to skin adaptation of T_reg cells.

a, Logos for the bZIP motifs highlighted in Fig. 4a (obtained from homer). b, Chromatin accessibility around genomic sites for additional bZIP motifs. c, Methylation (each row corresponds to a motif site ± 200 bases, each column corresponds to one of 3 donors, donors for skin Treg cells and blood CD45RA⁺ T_reg cells are unpaired) around genomic sites for bZIP motifs (n = 29,813 motif sites, 29,546 motif sites, 28,220 motif sites, 28,693 motif sites, 26,628 motif sites, 30,426 motif sites, 27,920 motif sites, 23,868 motif sites, 28,863 motif sites and 18,907 motif sites, respectively, from top to bottom). d, Logos for the bHLH motifs highlighted in Fig. 4c (obtained from homer). e, Chromatin accessibility around genomic sites for additional bHLH motifs. f, Methylation (each row corresponds to a motif site ± 200 bases, each column corresponds to one of 3 donors, donors for skin Treg cells and blood CD45RA⁺ T_reg cells are unpaired) around genomic sites for bHLH motifs. n = 12,050 motif sites, 11,186 motif sites, 9,358 motif sites, 11,415 motif sites and 3,004 motif sites, respectively, from top to bottom). g, Methylation, chromatin accessibility and USF1 ChIP-seq signal from three cell lines around interesting motif sites for USF1. Highlighted regions correspond to selected DMRs (methylation tracks), scATAC-seq peaks (chromatin accessibility tracks) and USF1 motif sites (motif ± 100 bases; ChIP-seq and gene tracks). Vertical lines at the bottom of the methylation tracks mark CpG sites. Parts of this panel are duplicated from Fig. 4g as they display the same genomic regions but focus on a different transcription factor. Data are representative of two or more independent experiments with two or more individual donors.