Fig. 7: Several TE subfamilies are transcribed in skin T_reg cells.

a, Expression levels of TE subfamilies in skin T_reg, skin T_conv, blood CCR8⁺ T_reg, blood CD45RA⁺ T_reg (blood RA⁺ T_reg) and blood CD45RA⁺ T_conv (blood RA⁺ T_conv) cells with within-cell-type mean based on 4, 4, 5, 5 and 3 donors, respectively (Tissue Donors 7, 8, 10 and 11 and Blood Donors 3–12). Values equal to 0 are shown in light beige. TPM normalization reflects the expression level of a particular TE compared to the whole collection of TEs. b, Differential expression of TE subfamilies between skin T_reg cells and blood CD45RA⁺ T_reg cells. P values were determined by two-tailed Wald test implemented in DESeq2 (skin T_reg cell donors, n = 4; blood CD45RA⁺ T_reg cell donors, n = 5; donors are as in a) with a Benjamini–Hochberg correction. c, Methylation of annotated HERVIP10F-int and LTR45B insertion sites (with median) in skin T_reg, blood CCR8⁺ T_reg and blood CD45RA⁺ T_reg cells (top; n = 3 donors per cell type; Tissue Donors 7, 10 and 11 and Blood Donors 3–8) and distribution of differences in mean methylation (across the three donors) between any two cell types for each insertion site (bottom). Numbers indicate how many insertion sites displayed differences below and above 0.