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Cancer immunology

Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency

Nature Immunology volume 26, pages 1223–1224 (2025)Cite this article

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Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint blockade, but disrupting TGFβ signaling in HOBIT-expressing tumor-infiltrating lymphocytes enhances anti-tumor immunity.

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Fig. 1: TGFβ drives induction of TRM cell features and inhibits effector differentiation of CD8+ TILs.

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Authors and Affiliations

  1. Department of Internal Medicine, Hackensack University Medical Center, Hackensack Meridian Health, Hackensack, NJ, USA

    Dongmei Zhao

  2. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA

    Hai-Hui Xue

Authors
  1. Dongmei Zhao
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  2. Hai-Hui Xue
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Correspondence to Hai-Hui Xue.

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The authors declare no competing interests.

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Zhao, D., Xue, HH. Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency. Nat Immunol 26, 1223–1224 (2025). https://doi.org/10.1038/s41590-025-02224-5

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