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Neuroendocrine signaling

T cells fast-track gut signals to the brain

CD4+ T cells migrate from the gut and adipose tissue to the brain parenchyma, in mouse and human, transmitting information on diet and microbiome to the subfornical organ, altering feeding behavior.

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Fig. 1: Brain T cells control feeding behavior.

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Correspondence to Emanuela Pasciuto.

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Pasciuto, E., Liston, A. T cells fast-track gut signals to the brain. Nat Immunol 26, 1430–1431 (2025). https://doi.org/10.1038/s41590-025-02237-0

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