Extended Data Fig. 9: SATB1 regulates the quiescence of TPRO in a subset-specific manner.
From: SATB1 is a key regulator of quiescence in stem-like CD8+ T cells
a-b, Dot plots showing expression of cluster markers. Dot size denotes the number of cells with a particular gene expressed, and intensity of dot color indicates the expression level of RNA (a) and gene accessibility (b). c, Module scores of the top 100 differentially expressed genes from previously identified progenitor, effector, and exhausted CD8+ T cells for all subsets in sgCtrl and sgSatb1. d-e, Coverage plots showing ATAC tracks at Myb (d) and Tnfsf8 (e) loci in sgCtrl and sgSatb1 TPRO cluster, with gene expression levels displayed as violin plots on the right side. TSS represents the transcription start site, grey boxes under the track represent putative enhancers, and links between the enhancers and the promoter are associated with promoter-enhancer interaction. Red bars mark examples of differentially accessible enhancers between sgCtrl and sgSatb1 in the TPRO cluster.
