Extended Data Fig. 10: Single-cell RNAseq analysis of tumor infiltrating T cells. | Nature Immunology

Extended Data Fig. 10: Single-cell RNAseq analysis of tumor infiltrating T cells.

From: Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity

Extended Data Fig. 10

a, Left, Subclusters of intratumoral CD3+ T cells are compared between the treatment groups. T cell subsets are identified in these clusters. Right, Relative abundance of T cell subsets is shown as the fractions of total CD3+ T cells. b, CD8+ T cell population was further subclustered to identify subsets of CD8+ T cells infiltrating the tumors. c, Subsets of CD8+ T cells were identified by the expression of indicated marker genes. Tmem, memory CD8+ T cell; Tex_prog, progenitor exhausted CD8+ T cell; Tex_term, terminally exhausted CD8+ T cell. d, Relative abundance of different CD8+ T cell subsets in total CD8+ T cells. Memory CD8+ T cell population (green) expanded in treatment groups, especially in LTβR monotherapy and combination therapy groups, compared with the untreated group.

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