Extended Data Fig. 3: Correlation among DNA methylation, chromatin accessibility and gene expression in ILCPs. | Nature Immunology

Extended Data Fig. 3: Correlation among DNA methylation, chromatin accessibility and gene expression in ILCPs.

From: Epigenetic imprinting in innate lymphoid cell precursors directs the lineage segregation of innate lymphoid cells

Extended Data Fig. 3

a, Volcano plot showing DMRs and genes related to DMRs in their enhancers in ILCP2s compared to ILCP1s. The genes with hypomethylated DMRs in ILCP2s were shown in blue (methylation difference of DMR < -0.1, P < 0.05). The genes with hypermethylated DMRs of ILCP2s were shown in red (methylation difference of DMR > 0.1, P < 0.05). Statistical analyses were performed using Fisher’s exact test. b, Bar graph representing enrichment scores of genes with differentially hypomethylated WCG in enhancers (Diff-hypomethyl-WCG), genes with differentially hypermethylated GCH in enhancers (Diff-hypermethyl-GCH) and upregulated genes in TH1 + TH2 or TH17 cell differentiation KEGG pathways in ILCP2s compared to ILCP1s. Statistical analyses were performed using hypergeometric test. Data are representative of at least two independent experiments.

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