Our study defines and spatially maps skin fibroblasts in both health and disease. We categorize fibroblast subtypes based on their association with scarring risk across 23 skin diseases and perform cross-tissue comparisons to identify shared fibroblast states.
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References
Rieder, F. et al. Fibrosis: cross-organ biology and pathways to development of innovative drugs. Nat. Rev. Drug Discov. 24, 543–569 (2025). A review article that provides an overview of fibrosis in a drug discovery context.
Buechler, M. B. et al. Cross-tissue organization of the fibroblast lineage. Nature 593, 575–579 (2021). This paper uses scRNA-seq data to dissect fibroblast heterogeneity across tissues and species (mice and humans), providing evidence for shared states and universal fibroblast populations.
Korsunsky, I. et al. Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases. Med. 3, 481–518 (2022). This paper expands cross-tissue fibroblast populations to four human diseases.
Gao, Y. et al. Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation. Cancer Cell 42, 1764–1783 (2024). This paper reports an inflammatory myofibroblast population (MMP1+) across cancers that is associated with immunotherapy response, which we also identify in skin and non-skin diseases.
Krishnamurty, A. T. & Turley, S. J. Lymph node stromal cells: cartographers of the immune system. Nat. Immunol. 21, 369–380 (2020). This review highlights the role of sculpting immune niches in lymphoid tissue, and the evidence that suggests similar fibroblast roles in other human tissues.
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This is a summary of: Steele, L. et al. A single cell and spatial genomics atlas of human skin fibroblasts reveal shared disease-related fibroblast subtypes across tissues. Nat. Immunol. https://doi.org/10.1038/s41590-025-02267-8 (2025).
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Skin fibroblasts sculpt distinct stromal and immune niches across diseases. Nat Immunol 26, 1643–1644 (2025). https://doi.org/10.1038/s41590-025-02266-9
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DOI: https://doi.org/10.1038/s41590-025-02266-9
