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Cancer immunotherapy

The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia

Nature Immunology volume 26, pages 1635–1636 (2025)Cite this article

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A Publisher Correction to this article was published on 16 September 2025

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The pre-T cell receptor is essential for T cell development. It is also an emerging immunotherapy target.

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Fig. 1: Targeting the surface pre-TCRα chain inhibits malignant T cell growth.

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References

  1. Pölönen, P., Mullighan, C. G. & Teachey, D. T. Blood 145, 1464–1474 (2025).

    Article  PubMed  Google Scholar 

  2. Fuentes, P. et al. Nat. Immunol. https://doi.org/10.1038/s41590-025-02265-w (2025).

    Article  PubMed  Google Scholar 

  3. Ciantra, Z., Paraskevopoulou, V. & Aifantis, I. Nat. Immunol. 26, 351–365 (2025).

    Article  PubMed  CAS  Google Scholar 

  4. Patel, K. K., Tariveranmoshabad, M., Kadu, S., Shobaki, N. & June, C. Mol. Ther. 33, 2123–2140 (2025).

    Article  PubMed  CAS  Google Scholar 

  5. Gower, M. & Tikhonova, A. N. Blood 140, 3–4 (2022).

    Article  PubMed  CAS  Google Scholar 

  6. Spits, H. Nat. Rev. Immunol. 2, 760–772 (2002).

    Article  PubMed  CAS  Google Scholar 

  7. von Boehmer, H. et al. Immunol. Rev. 165, 111–119 (1998).

    Article  Google Scholar 

  8. Gerby, B. et al. Leukemia 25, 1249–1258 (2011).

    Article  PubMed  CAS  Google Scholar 

  9. Maciocia, P. M. et al. Blood 140, 25–37 (2022).

    Article  PubMed  CAS  Google Scholar 

  10. Sánchez-Martínez, D. et al. Blood 133, 2291–2304 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ali, M. et al. Nat. Biotechnol. 40, 488–498 (2022).

    Article  PubMed  CAS  Google Scholar 

  12. Gordon, P. M. et al. Blood Neoplasia 2, 100120 (2025).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology and Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA

    Aliza Rosen & Iannis Aifantis

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  1. Aliza Rosen
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  2. Iannis Aifantis
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Correspondence to Iannis Aifantis.

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The authors declare no competing interests.

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Rosen, A., Aifantis, I. The pre-T cell receptor as a tumor immunotherapy target in T cell leukemia. Nat Immunol 26, 1635–1636 (2025). https://doi.org/10.1038/s41590-025-02269-6

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