Extended Data Fig. 2: Expression of IL-18 related genes across subsets in the thymus.
From: Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
a, Relative expression of Il18, Il18r1 and Il18rap on subsets of thymus populations at baseline in 1mo mice (n = 2). Data extracted from Gene Expression Commons using the “Complete thymocyte:stromal interaction model dataset” (https://gexc.riken.jp/models/475/) which is based on GSE56928 (ref. 26). b, UMAPs from scRNAseq described in Fig. 2a with color overlays indicating dataset (Left, Rag2-GFP− CD45+ or CD45-) or timepoint (right, d0, 1, 4, 7 after SL-TBI). c, Il18 relative expression measured by qPCR within cDC1, cDC2, MECs, and Macrophages FACS isolated (see Extended Data Fig. 3 for gating) from thymuses of female 1-2 mo C57/BL6 WT mice (n = 4/group). Graphs represent mean ± SEM; each dot represents an individual biological replicate.
