The effector fates of innate lymphoid cells (ILCs) are epigenetically imprinted early in ontogeny through the selective loss of DNA methylation at signature genes encoding fate-determining regulators — a process that is important for functional diversification of barrier immunity.
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Gamble, N., Sun, M. & Koh, A.S. DNA hypomethylation primes ILC lineage choice. Nat Immunol 26, 1628–1630 (2025). https://doi.org/10.1038/s41590-025-02275-8
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DOI: https://doi.org/10.1038/s41590-025-02275-8
