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TFH cells

TFH cell programs by pathogen and species

Nature Immunology volume 26, pages 1631–1632 (2025)Cite this article

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CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential.

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Fig. 1: Representation of TFH cell core and pathogen-specific gene programs.

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Authors and Affiliations

  1. Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA

    Amy S. Weinmann

  2. Lymphocyte Transcriptional Regulation Unit, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA

    Danielle A. Chisolm

  3. Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA

    Danielle A. Chisolm

Authors
  1. Amy S. Weinmann
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  2. Danielle A. Chisolm
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Correspondence to Amy S. Weinmann or Danielle A. Chisolm.

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The authors declare no competing interests.

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Weinmann, A.S., Chisolm, D.A. TFH cell programs by pathogen and species. Nat Immunol 26, 1631–1632 (2025). https://doi.org/10.1038/s41590-025-02284-7

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