The artificial intelligence (AI)-designed peptide SK56 blocks mature gasdermin D pores, delaying pyroptosis and inflammatory cytokine release. This reduces dendritic cell hyperactivation and prevents the spread of pyroptosis to nearby cells. SK56 also protects against mitochondrial damage and improves survival in septic mice, demonstrating its potential as a new post-pyroptosis, anti-inflammatory therapy.
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References
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This is a summary of: Sun, J. et al. Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. Nat. Immunol. https://doi.org/10.1038/s41590-025-02280-x (2025).
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Precise inhibition of pyroptotic pores presents new opportunities for inflammation therapy. Nat Immunol 26, 1637–1638 (2025). https://doi.org/10.1038/s41590-025-02294-5
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DOI: https://doi.org/10.1038/s41590-025-02294-5
