Extended Data Fig. 8: Additional population differences in the antiviral antibody repertoire.
a, −log10(adjusted P-values) against effect sizes for associations between the AVARDA breadth score and continent of birth in the EIP cohort (two-sided Wald test). Each point indicates a virus, colored according to its viral family. b,c, −log10(adjusted P-values) of associations between continent of birth and HHV-8 (b) and CMV (c) peptide Z-scores, separated by viral protein, in the EIP cohort (two-sided Wald test). The strength and direction of associations are indicated by the size and direction of triangles, respectively. Non-significant associations are colored gray. d, −log10(adjusted P-values) and direction of associations between all public peptide Z-scores and continent of birth in the EIP cohort, separated by viral species, after adjusting on genotypes of the lead variants identified by GWAS (Supplementary Table 7) (two-sided Wald test). The dashed gray vertical lines indicate viruses for which the AVARDA breadth score is significantly associated with continent of birth. The dashed red horizontal lines indicate the significance threshold (Padj < 0.05). e, −log10(adjusted P-values) against effect sizes for associations between IAV peptide Z-scores and continent of birth in the EIP cohort, faceted by main IAV subtypes (two-sided Wald test). Colors indicate the viral protein. f,g, Amino-acid positions of the midpoint of HA (f) and NP (g) peptides associated with continent of birth within the full IAV proteins for the EIP cohort (two-sided Wald test). The significance and direction of associations with age are indicated on the y-axis and by the direction of triangles, respectively. The triangle color indicates the IAV subtype.
