Fig. 3: Antiviral antibody repertoire in relation to continent of birth. | Nature Immunology

Fig. 3: Antiviral antibody repertoire in relation to continent of birth.

From: Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

Fig. 3

a, −log10(Padj) values and the directions of associations between all public peptide Z scores and continent of birth in the EIP cohort, separated by viral species (two-sided Wald test). The dashed gray vertical lines indicate viruses for which the AVARDA breadth score is significantly associated with continent of birth. The dashed red horizontal lines indicate the significance threshold (Padj < 0.05). b, −log10(Padj) values against effect sizes of associations between continent of birth and peptide Z scores from the EBV AG876 strain in the EIP cohort (two-sided Wald test). Colors indicate the viral protein. c,d, PhIP-seq reactivity scores (c) and Luminex-based titers (d) for antibodies targeting the most significant EBNA-4 peptide (UniProt ID: Q1HVG4) from the EBV AG876 strain, in AFB and EUB separately. Horizontal lines, box edges and whiskers indicate the median value, interquartile range and 1.5× the interquartile range, respectively. e, Amino acid positions of the midpoint of public EBNA-4 peptides associated with continent of birth within the full EBV EBNA-4 protein for the EIP cohort (two-sided Wald test). Significance and the directions of associations with age are indicated on the y axis and by the direction of triangles, respectively. Triangle colors indicate the EBV strain. f, −log10(Padj) values against effect sizes of associations between continent of birth and peptide Z scores from the EBV B95-8 strain in the EIP cohort (two-sided Wald test). Colors indicate the viral protein. g,h, PhIP-seq reactivity scores (g) and Luminex-based titers (h) for antibodies targeting the most significant EBNA-6 peptide (UniProt ID: P03204) from EBV B95-8, in AFB and EUB separately. Horizontal lines, box edges and whiskers indicate the median value, interquartile range and 1.5× the interquartile range, respectively. i, Amino acid positions of the midpoint of all public EBNA-6 peptides associated with continent of birth within the full EBV EBNA-6 protein for the EIP cohort (two-sided Wald test). Significance and the directions of associations with age are indicated on the y axis and by the direction of triangles, respectively. Triangle colors indicate the EBV strain.

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