Fig. 6: Variance in antiviral antibody reactivity explained by demographic and genetic factors. | Nature Immunology

Fig. 6: Variance in antiviral antibody reactivity explained by demographic and genetic factors.

From: Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

Fig. 6

a, Proportion of variance explained by demographic (that is, age, sex and smoking) and genetic factors for antibody reactivity against 2,608 public peptides in the Milieu Intérieur cohort. The peptides are sorted by total variance explained. b, Variance explained by age and IGH genetic variation for RSV protein G peptides in the Milieu Intérieur cohort, colored according to RSV strain, as in c. c, Hierarchical clustering of peptide sequences from RSV protein G, separating peptides affiliated with the RSV-A (green) and RSV-B (blue) strains. d, Amino acid positions of the midpoint of protein G peptides associated with age and IGH genetic variation within the full RSV protein G for the Milieu Intérieur cohort (two-sided Wald test). P values for the association with age (beige) and the most significant IGH variant (black) are indicated, separated by RSV strain. Significance and directions of associations are indicated on the y axis and by the direction of triangles, respectively. The dotted red horizontal lines indicate the significance threshold (Padj < 0.05).

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