Extended Data Fig. 3: Validation of AVARDA scores by comparisons with ELISA- and Luminex-based serostatuses in the Milieu Intérieur cohort. | Nature Immunology

Extended Data Fig. 3: Validation of AVARDA scores by comparisons with ELISA- and Luminex-based serostatuses in the Milieu Intérieur cohort.

From: Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

Extended Data Fig. 3

a,g, −log10(P-values) for the association between serology determined by (a) ELISA or (g) Luminex xMAP and the AVARDA breadth scores. Serology variables are plotted on the x-axis. The top two AVARDA associations are connected by a black vertical line. Significant associations (FDR < 0.05) are colored in green or red if the association is or is not for the cognate virus, respectively. Non-significant associations are colored gray. b-f, −log10(P-values) for the association between the AVARDA breadth scores and ELISA-based serostatus for (b) CMV, (c) EBV VCA antigen, (d) rubella virus, (e) IAV, and (f) hepatitis B. h-l, −log10(P-values) for the association between the AVARDA breadth scores and Luminex-based serology for (h) CMV, (i) EBV VCA antigen, (j) rubella virus, (k) IAV, and (l) hepatitis B. Significant associations (FDR < 0.05) are colored in green or red if the association is or is not for the cognate virus, respectively. Non-significant associations are colored gray.

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