Fig. 1: Analysis and validation populations.

Individual participant data from three trials were pooled for analysis. The original results were published in ref. 1 (OFLOTUB), ref. 2 (REMoxTB) and ref. 3 (RIFAQUIN). Data from a fourth trial, DMID 01-009, were used for external validation and previously published in ref. 9. The modified intent-to-treat population was used for the analysis. aFor the validation dataset, the time-to-event analysis population in the original publication was used. bREMoxTB included two 4-month experimental groups.