Extended Data Fig 3: Visual acuity results at baseline and months 1 through 6 following injection(s). | Nature Medicine

Extended Data Fig 3: Visual acuity results at baseline and months 1 through 6 following injection(s).

From: Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

Extended Data Fig 3

a, Visual acuity results recorded in both eyes of all ten subjects as of the interim analysis cut-off date. Treated eyes are larger up-triangles and untreated contralateral eyes are smaller down-triangles. Minor shifts are introduced to allow visibility of symbols that would otherwise overlap. b, Change in acuity from baseline. The first 3 months of the graph are duplicated in Fig. 1d of the main report. c, Interocular difference (treated eye minus untreated eye) between acuities. Larger symbols in panels b and c are averages from 10 patients at baseline and month 1, 8 patients at months 2 and 3, 6 patients at months 4 and 5, and 4 patients at month 6. Smaller symbols show the individual data points. Error bars, ±1 s.d. Linear mixed-effects models were used for the statistical analysis

Back to article page