Extended Data Fig. 6: Additional validation data for ADAR dependence.
From: Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
a, ADAR depletion by Dox-inducible shRNAs assessed by western blots and growth effects assessed by colony formation assays. Similar results were obtained for MDA-MB-468, HSC4 and SW1990 in two additional experiments. Blot images are cropped to show the relevant bands, and molecular mass markers are indicated (in kD). See Source Data for the uncropped western blots. b, ADAR RNA levels in CAL27 xenograft tumors. Data are mean ± s.e.m., n = 3 mice for each group.
