Extended Data Fig. 3: Two metagenomic cohorts identify clear but only partially overlapping microbiome signatures associated with CRC. | Nature Medicine

Extended Data Fig. 3: Two metagenomic cohorts identify clear but only partially overlapping microbiome signatures associated with CRC.

From: Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Extended Data Fig. 3

a,b, Relative abundances (log scale) and effect sizes (estimated using the linear discriminant analysis score in LEfSe) for the significantly different microbial species in CRC samples compared to control samples for Cohort1 (significance assessed by the non-parametric test in LEfSe) (a) and Cohort2 (b). c, Alpha-diversities measured as the total number of species and total number of UniProt90 gene families in each sample for the two cohorts. d, Beta-diversities estimated with the Bray–Curtis dissimilarity metric for intra- and inter-condition comparisons in the two cohorts.

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