Extended Data Fig. 1: Circulating KRIS proteins are enriched in TNF-RSF members. | Nature Medicine

Extended Data Fig. 1: Circulating KRIS proteins are enriched in TNF-RSF members.

From: A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

Extended Data Fig. 1

a, Distribution of the inflammatory classes among a proteomic platform (SOMAscan) array; and b, within the KRIS in the Joslin cohorts (n = 363). A two-sided Fisher’s exact test detected enrichment in TNF-RSF members (P = 0.007, the class marked in dark red), but not in other inflammatory classes (shades of gray). Results extracted from the multivariate screen – volcano plot (Fig. 1a). ILEU, interleukins; ILEUR, interleukin receptors; CHK, chemokines; CHKR, chemokine receptors; CPL, complement proteins; IFN, interferons; TNFL, TNF superfamily ligands; TNF-RSF, TNF-receptor superfamily members, VR, varia or other inflammatory proteins.

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