Extended Data Fig. 3: Orthogonal relationships among circulating KRIS proteins.

a, Hierarchical cluster analysis in the Joslin cohort with T1D, n = 219. b, Joslin cohort with T2D, n = 144. c, Spearman’s rank correlation matrix in the two Joslin cohorts, n = 363. a, b, Distances are shown (Ward’s method). TNF-RSF members are marked in red. c, Spearman’s correlation matrix represents relationships among proteins in the two cohorts in the analysis adjusted for the cohort indicator. Coefficients (r) are presented. Color intensity corresponds to the effect size (r).