Extended Data Fig. 1: Stratification of ‘resisters’ and LTBI controls by IGRA, TST and BCG scar.
From: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
a–c, IGRA results (a) are shown by the average of three sequential QFT-Gold readings minus the background (nil) stratified across RSTR (n = 40) or LTBI (n = 39). TST results, stratified across RSTR or LTBI, are reported in mM of induration measured in phase 1 (b) and phase 2 (c) of the clinical trial. Medians are depicted by lines with interquartile ranges. d,e, Plasma levels of IgG reactive to PPD (d) and ESAT6 and CFP10 (e) were quantified in RSTR (n = 40) and LTBI (n = 39) individuals using a customized multiplex Luminex in serial dilutions. AUCs were determined from MFIs generated with each dilution and plotted for each individual. Data points are stratified by BCG scar status. Statistical significance was calculated by Mann–Whitney U test and two-tailed P values are indicated.
