Extended Data Fig. 7: Metabolite changes in colorectal cancer stages. | Nature Medicine

Extended Data Fig. 7: Metabolite changes in colorectal cancer stages.

From: Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

Extended Data Fig. 7

Sixty-five metabolites with statistically significant (P < 0.005; one-sided Mann–Whitney U test) differences for any of the stages (MP, n = 45; S0, n = 30; SI/II, n = 80; SIII/IV, n = 68 compared to the healthy controls (n = 149) on capillary electrophoresis time of flight mass spectrometer (CE-TOFMS) analysis. Significant changes (elevation and depletion) are denoted as follows: +++, elevation with P < 0.005; ++, elevation with P < 0.01; +, elevation with P < 0.05; −−−, depletion with P< 0.005; −−, depletion with P < 0.01; −, depletion at P < 0.05. The boxes represent 25th–75th percentiles, black lines indicate the median, whiskers extend to the maximum and minimum values within 1.5× the interquartile range and dots indicate outliers.

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