Extended Data Fig. 2: Cell morphology study in primary HDLECs.
From: ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor
Primary HDLECs transduced with ARAF-WT or ARAF-S214P were plated in the presence or absence of 100 nM trametinib. Cells were fixed and stained for VE-cadherin and actin. Here are the full ×10 magnification fields. a, VE-cadherin staining. b, Actin staining of the same ×10 field shown in a. c, Zoomed-in views of the regions with the red boxes in b. Zoomed-in views are presented for improved visualization of the actin filaments.
