Extended Data Fig. 7: Peripheral artery disease risk variants and association with LAS and CAD.
From: Genome-wide association study of peripheral artery disease in the Million Veteran Program
For the 19 PAD risk variants identified in our study, logistic regression Z-scores of association (aligned to the PAD risk allele) were obtained from MVP (PAD, N = 31,307 PAD cases and 211,753 controls) and publicly available summary statistics for large artery stroke (MVP+MEGASTROKE consortium25, N = 7,393 LAS cases and 628,737 controls) and coronary artery disease (MVP+CARDIoGRAMplusC4D consortium24, N = 111,216 CAD cases and 248,081 controls). A positive Z-score (red) indicates a positive association between the PAD risk allele and the disease, while a negative Z-score (blue) indicates an inverse association. Boxes are outlined in cyan if the variant is uniquely associated with PAD (two-sided logistic regression PPAD < 5 × 10−8, PCAD and PLAS > 0.05).
