Extended Data Fig. 8: Peripheral artery disease risk variants and mechanistic overlap with LAS and CAD.
From: Genome-wide association study of peripheral artery disease in the Million Veteran Program
Venn diagram of each of the 19 PAD risk loci in a based on their association with PAD (N = 31,307 PAD cases and 211,753 controls; two-sided PPAD < 5 × 10−8), CAD (N = 111,216 CAD cases and 248,081 controls; two-sided P < 0.05) and LAS (N = 7,393 LAS cases and 628,737 controls; two-sided P < 0.05) using logistic regression. Each locus is depicted along with the plausible relationship to the underling causal risk factor separately by color. Loci names are based on the nearest genes; however, the causal gene(s) remains unclear for some associated loci and as such, the resultant annotation may prove incorrect in some cases.
