Extended Data Fig. 4: TCF7L2 mediates its effect on PAD via T2D.
From: Genome-wide association study of peripheral artery disease in the Million Veteran Program
a, Forest plot depicting the replication of the known TCF7L2/rs7903146-T2D association signal12 in MVP for both white and black participants. b, The same variant is also associated with PAD risk in whites and blacks in MVP. However, when controlling for T2D status in the regression model, c, the association signal is dramatically reduced, suggesting that TCF7L2 PAD risk is mediated through its effect on T2D. Logistic regression two-sided values of P are displayed. Gray boxes reflect the inverse-variance weight for each ancestry.
