Extended Data Fig. 5: Forest plot for association of the CHRNA3 locus and peripheral artery disease risk stratified by smoking status.
From: Genome-wide association study of peripheral artery disease in the Million Veteran Program
When stratifying European MVP participants by smoking status (ever smokers versus never smokers), nearly all the association signal resides within the ever smoker group. Previous reports of variation at the CHRNA3 locus demonstrate that carriers of the PAD risk allele have a reduced likelihood of cigarette smoking cessation9. This suggests that the PAD-CHRNA3 association is driven by a greater burden of tobacco exposure in those who carry the nicotine dependence/PAD risk allele. Logistic regression two-sided values of P are displayed. Gray boxes reflect the inverse-variance weight for each subgroup.
