Extended Data Fig. 7: WT mice transplanted with progeroid microbiota show metabolic alterations.
From: Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
a, Comparison of the body weight between female WT mice transplanted with progeroid microbiota (WT-oG609Gmic; n = 7) and female WT controls (n = 7) over the indicated time period. Differences of body weight over the time were assessed with a linear mixed model and analyzed with an ANOVA type II Wald χ2 test (χ2 = 15.98, d.f. = 1, P = 6.3 × 10−5). Data are presented as mean ± s.e.m. b–d, Metabolic parameters, measured with an Oxymax system, of WT (n = 14; 7 males and 7 females) and WT-oG609Gmic (n = 14; 7 males and 7 females) mice. Comparison of O2 consumption (b), CO2 production (c) and energy expenditure (d) over the indicated period of time. Smoothing curves represent the means of all individuals in each group and shaded areas represent 95% CI.
