Extended Data Fig. 8: Zmpste24−/− female mice transplanted with wild-type (WT) gut microbiota show an improved phenotype and extended maximal survival.
From: Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
a, Comparison of the body weight between control Zmpste24−/− mice (n = 7) and Zmpste24−/− mice transplanted with WT microbiota (Zmpste24−/−-WTmic, n = 7) over the indicated time period. Differences in body weight over the time were assessed with a linear mixed model and analyzed with an ANOVA type II Wald χ2 test (χ2 = 10.52, d.f. = 1, P = 0.0011). b, Comparison of the number of mice dead and alive between Zmpste24−/− (Ctrl; n = 7) and Zmpste24−/− transplanted with WT microbiota (WTmic; n = 7) at the 80th percentile of overall survival. Differences were analyzed by one-sized Fisher’s exact test (P = 0.09).
