Extended Data Fig. 1: GS-CA1 antiviral activity against HIV-2 and SIV. | Nature Medicine

Extended Data Fig. 1: GS-CA1 antiviral activity against HIV-2 and SIV.

From: A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Extended Data Fig. 1

a, Antiviral activity of GS-CA1 against one HIV-2 and two SIV isolates replicating in human PBMCs. Center line and error bars represent mean ± s.d. values determined 7 d post-infection using a reverse transcriptase (RT) activity readout. Experiment was performed once using triplicate cell cultures. b, Alignment of capsid amino-acid sequences. Dots represent invariant residues. Red arrows highlight HIV-1 residues associated with GS-CA1 resistance.

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