Extended Data Fig. 3: GS-CA1 resistance mutations map to a conserved CA subunit interface. | Nature Medicine

Extended Data Fig. 3: GS-CA1 resistance mutations map to a conserved CA subunit interface.

From: A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Extended Data Fig. 3

a, Location of the resistance-defined GS-CA1 binding site (highlighted by orange rectangle) within the HIV-1 CA hexamer structure (ref. 13). The resistance-defined GS-CA1-binding subunit is shown in blue and the adjacent CA subunit in silver. b, Location of CA residues associated with GS-CA1 resistance (pink spheres), with CA-binding peptides from cleavage and polyadenylation specificity factor 6 (CPSF6313–327) in yellow and nucleoporin 153 (Nup1531410–1423) in green (ref. 17). CPSF6 Phe321 and Nup153 Phe1417 side chains highlighted in stick mode. c, GS-CA1 binding site conservation. The percent CA conservation is depicted as a heat-map based off >4,400 HIV-1 subtype B sequences.

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