Extended Data Fig. 1: Phylogenetic trees for paired tumor biopsies.

Phylogenetic trees for patients with WES for pre- and post-treatment samples. The numbers of somatic alterations assigned to each cluster and detected events in known cancer genes appear on the branches. Two-dimensional plots show the CCF distributions of subclones in the pre- and post-treatment samples. Events in known cancers are shown next to their subclonal cluster.